Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively.1,2 It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM).3 In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.4,5
1.Thibonnier, M., Bayer, A.L., Simonson, M.S., et al.Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cellsEndocrinology129(6)2845-2856(1991) 2.Xu, Y.J., and Gopalakrishnan, V.Vasopressin increases cytosolic free [Ca2+] in the neonatal rat cardiomyocyte. Evidence for V1 subtype receptorsCirc. Res.69(1)239-245(1991) 3.Byron, K.L.Vasopressin stimulates Ca2+ spiking activity in A7r5 vascular smooth muscle cells via activation of phospholipase A2Circ. Res.78(5)813-820(1996) 4.Gao, L., Jiang, N.-C., Luo, Q.-H., et al.Cardiovascular effects of injection of argipressin into lateral septal nuclei in ratsZhongguo Yao Li Xue Bao.17(1)49-52(1996) 5.Jiang, N.-C., Gao, L., Chen, C., et al.Effects of argipressin injected into medial amygdaloid body on blood pressure and heart rate in ratsZhongguo Yao Li Xue Bao.14(2)118-120(1993)