GlpBio

Apronal (Allylisopropylacetylurea)

目录号: GC33737纯度: >98.00%同义词: 丙戊酰脲; Allylisopropylacetylurea; Apronalide
A muscle relaxant
Apronal (Allylisopropylacetylurea)
Cas No.: 528-92-7
规格价格库存数量操作
100mg¥210.00现货
1
10mM (in 1mL DMSO)¥385.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Apronal is a muscle relaxant.1 It prolongs methylhexabital-induced sleep and enhances morphine-induced analgesia in dogs, mice, and rats. Apronal has been used to induce experimental porphyria in rabbits.2 Formulations containing apronal have previously been used as daytime sedatives.

1.Yajima, T., Uritani, K., Aoki, R., et al.Pharmacological studies on allylisopropylacetylurea (apronalide), a drug with central nervous system activityOyo Yakuri11(5)693-717(1976) 2.Schmid, R.M., and Schwartz, S.Experimental porphyria. III. Hepatic type produced by sedormidProc. Soc. Exp. Biol. Med.81(3)685-689(1952)

实验参考方法 Experimental Reference Method

Animal experiment:

Rats: Apronal is administered to male Sandoz OFA-SPF rats, weighing 140-150 g in two equal daily subcutaneous injections 8 h apart. The overall daily dose is 400 mg/kg and dosing is continued for 21 days. Control rats are similarly treated with propandiol only. Urine samples are collected in glass tubes at solid CO2, temperatures and stored frozen until analysis[1].

References:

[1]. Rentsch G, et al. The effect of prolonged administration of allylisopropylacetylurea to rats on cytochrome P-450 and other liver haemoproteins. Xenobiotica. 1976 Mar;6(3):151-7.
[2]. Fujimoto Y, et al. Fixed drug eruption due to allylisopropylacetylurea. Contact Dermatitis. 1993 May;28(5):282-4.

产品文档 Product Documents

Purity:>98.00%

化学性质Chemical Properties

CAS 号
528-92-7
同义词
丙戊酰脲; Allylisopropylacetylurea; Apronalide
SMILES
C=CCC(C(C)C)C(NC(N)=O)=O
分子式
C9H16N2O2
分子量
184.24 g/mol
溶解性
DMSO : ≥ 165 mg/mL (895.57 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol