Apramycin is an aminoglycoside antibiotic first isolated from S. tenebrarius.1 It is active against a variety of Gram-positive and Gram-negative bacteria, including strains which produce aminoglycoside-modifying enzymes.2 Apramycin inhibits protein synthesis in bacteria both in vivo and in vitro.1
1.Perzynski, S., Cannon, M., Cundliffe, E., et al.Effects of apramycin, a novel aminoglycoside antibiotic on bacterial protein synthesisEur. J. Biochem.99(3)623-628(1979) 2.Abe, Y., Nakagawa, S., Naito, T., et al.Aminoglycoside antibiotics. XIV. Synthesis and activity of 6-O-(3-amino-3-deoxy-α-D-glucopyranosyl)-and 5-O-(β-D-ribofuranosyl)apramycinsJ. Antibiot. (Tokyo)34(11)1434-1446(1981)