GlpBio

Antisauvagine-30 (trifluoroacetate salt)

目录号: GC49209纯度: >95.00%同义词: AS30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, D-Phe11,His12Svg11-40, aSVG, aSvg-30
A peptide CRF2 antagonist
Antisauvagine-30 (trifluoroacetate salt)
Cas No.: N/A
规格价格库存数量操作
1 mg¥7,946.00现货
1
500 µg¥4,666.00现货
1
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产品描述 Description

Antisauvagine-30 is a peptide antagonist of corticotropin-releasing factor receptor 2 (CRF2).1,2 It is selective for CRF2α over CRF1 (Kis = 1.75 and 915 nM, respectively for the human receptors).1 Antisauvagine-30 (10 nM) inhibits sauvagine-induced cAMP production in HEK293 cells expressing mouse CRF2β.2 It prevents stress-induced contextual fear conditioning in mice.3 Antisauvagine-30 reduces vasoactive intestinal peptide-induced decreases in food intake in rats.4

1.Dautzenberg, F.M., Py-Lang, G., Higelin, J., et al.Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: Evidence for evolutionary differencesJ. Pharmacol. Exp. Ther.296(1)113-120(2001) 2.RÜhmann, A., Bonk, I., Lin, C.R., et al.Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): Development of CRFR2β-selective antisauvagine-30Proc. Natl. Acad. Sci. USA95(26)15264-15269(1998) 3.Sananbenesi, F., Fischer, A., Schrick, C., et al.Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: A possible link between stress and fear memoryJ. Neurosci.23(36)11436-11443(2003) 4.Garnica-Siqueira, M.C., Martins, A.B., Zaia, D.A.M., et al.Corticotrophin-releasing factor mediates vasoactive intestinal peptide-induced hypophagia and changes in plasma parametersHorm. Behav.105138-145(2018)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
N/A
同义词
AS30, D-FHLLRKMIEIEKNEKEKNNAANNRLLLDTI-NH2, D-Phe11,His12Svg11-40, aSVG, aSvg-30
SMILES
O=C([C@@H](CC1=CC=CC=C1)N)N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@@]([H])([C@H](CC)C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@]([H])(C(N[C@@]([H])([C@H](CC)C)C(N)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCC(N)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)CCC(N)=O)=O)CCCCN[H])=O)CCC(O)=O)=O)=O)CCC(O)=O)=O)=O)CCSC)=O)CCCCN[H])=O)CCCNC(N)=N)=O)=O)=O)CC2=CNC=N2.OC(C(F)(F)F)=O
分子式
C161H274N48O46S·XCF3COOH
分子量
3650.3 g/mol
溶解性
Water: soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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