Antiproliferative agent-37 (compound 10J) shows anti-proliferative effect by arresting the cells at the G2/M phase of the cell cycle.
Antiproliferative agent-37 (compound 10J) shows cytotoxic/cytostatic effect against A431, HT1080, MCF-7, MDA-MB-231, and AG01523 cell strains, with IC50 values of 0.013±0.004, 0.014±0.008, 0.14±0.04, 0.018±0.009, 56.3±4.3 μM, respectively[1].
References:
[1]. Lougiakis N, et al. Synthesis, cytotoxic activity evaluation and mechanistic investigation of novel 3,7-diarylsubstituted 6-azaindoles. Eur J Med Chem. 2023 Sep 13;261:115804.