Anticonvulsant agent 2 is a potent and orally active anticonvulsant agent. Anticonvulsant agent 2 shows antiepileptic activity[1].
Anticonvulsant agent 2 (compound10 a; 50 mg/kg, p.o.) 降低大鼠运动活性，抑制率为 21.01%[1]。
Anticonvulsant agent 2 (50 mg/kg; p.o.) 显示出抗癫痫活性，对大鼠的抑制率为24.45%[1]。
| Animal Model: | 180-250g, male Wistar rats[1] |
| Dosage: | 50 mg/kg |
| Administration: | P.o. |
| Result: | Showed antiepileptic activity with the inhibition rate of 24.45%. |
[1]. Verma R, et al. Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents. Bioorg Chem. 2020 Aug;101:104010.