GlpBio

Amycolatopsin A

目录号: GC48339纯度: >95.00%
A macrolide polyketide with antimycobacterial and anticancer activities
Amycolatopsin A
Cas No.: 2209112-96-7
规格价格库存数量操作
1mg¥4,112.00现货
1
5mg¥14,337.00现货
1
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文献被引

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    641, 529–536 (2025)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

产品描述 Description

Amycolatopsin A is a macrolide polyketide originally isolated from Amycolatopsis that has antimycobacterial and anticancer activities.1 It is active against M. bovis and M. tuberculosis (IC50s = 0.4 and 4.4 µM, respectively) but not B. subtilis, S. aureus, E. coli, or P. aeruginosa (IC50s = >30 µM for all). Amycolatopsin A is cytotoxic to SW620 colorectal and NCI H460 lung cancer cells (IC50s = 0.08 and 1.2 µM, respectively).

1.Khalil, Z.G., Salim, A.A., Vuong, D., et al.Amycolatopsins A-C: Antimycobacterial glycosylated polyketide macrolides from the Australian soil Amycolatopsis sp. MST-108494J. Antibiot. (Tokyo)70(12)1097-1103(2017)

产品文档 Product Documents

Purity:>95.00%

化学性质Chemical Properties

CAS 号
2209112-96-7
SMILES
CC1C(O[C@@H]2[C@H](O)[C@@H](O)[C@H](OC)[C@@H](C)O2)/C(C)=C/C(C)=C/C(C)=C/C(O)C(OC)CC([C@@H](C)[C@@]3(O)[C@H](OC)[C@@H](O)[C@@](O[C@@H]4O[C@H](C)[C@@H](O[C@@]5([H])C[C@@](C)(O)[C@H](O)[C@@H](C)O5)[C@@H](O)C4)(C)[C@@H](CCCOC)O3)OC(/C(C)=C/C(OC)=C\C(CO)=C/1)=O
分子式
C60H98O23
分子量
1187.4 g/mol
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol