AMPR-22 is a synthetic antimicrobial peptide derived from the mitochondrial cation channel reactive oxygen species (ROS) modulator 1 (Romo1).1 It is active against S. aureus, methicillin-resistant S. aureus (MRSA), P. aeruginosa, and carbapenem-resistant P. aeruginosa with minimum bactericidal concentration (MBC) values of 2, 2, 2, and 4 µg/ml, respectively. AMPR-22 induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa in a concentration-dependent manner. It increases survival in a mouse model of sepsis induced by S. aureus when administered at a dose of 10 mg/kg.
1.You, D.-G., Lee, H.-R., Kim, H.-K., et al.A novel peptide derived from the transmembrane domain of Romo1 is a promising candidate for sepsis treatment and multidrug-resistant bacteriaInt. J. Mol. Sci.22(15)8243(2021)