Amoxicillin trihydrate is a penicillin-structural similar to ampicillin and broad spectrum antibiotic [1].
Amoxicillin trihydrate has shown an antibacterial spectrum comparable to that of ampicillin and be better absorbed after oral administration. In addition, the antibacterial activity of Amoxicillin trihydrate against approximately 30 isolates each of Escherichia coli, Proteus mirabilis, Kiebsiella, Enterobacter, andindole-positive Proteus specie with the MIC values of 0.01μg/ml, 0.25μg/ml and 50μg/ml for Str.viridans, Bacillus anthracis and P.rettgeri, respectively. Apart from these, Amoxicillin trihydrate has been found to produce substantially higher serum levels than the same dose of ampicillin [1,2,3].
References:
[1] H. Hunter Handsfield, Hugh Clark, James F. Wallace, King K. Holmes and Marvin Turck Amoxicillin, a New Penicillin Antibiotic
[2] Bodey GP, Nance J. Amoxicillin: in vitro and pharmacological studies. Antimicrob Agents Chemother. 1972 Apr;1(4):358-62.
[3] Bodey GP, Nance J. Amoxicillin: in vitro and pharmacological studies. Antimicrob Agents Chemother. 1972 Apr;1(4):358-62.