氨肽酶 N/APN 蛋白是一种广泛特异性的氨肽酶，其功能为通过二硫键连接的同源三聚体。它在胃蛋白酶和胰蛋白酶对蛋白质水解产生的肽的最终消化中起着至关重要的作用。此外，它还参与多种肽的加工，包括血管紧张素 III 和 IV 等肽激素、神经肽和趋化因子。此外，它可能参与抗原呈递细胞中与主要组织相容性复合物 II 类分子结合的肽的裂解。这种蛋白质还可能有助于血管生成并促进胆固醇结晶。此外，它作为氨基酸转运蛋白 SLC6A19 的结合伴侣，可能调节其活性并影响氨基酸转运。值得注意的是，氨基肽酶 N/APN 蛋白充当人类冠状病毒 229E/HCoV-229E 的受体，特别是在感染期间充当 HCoV-229E 刺突糖蛋白的受体。
Aminopeptidase N/APN Protein, Human (HEK293, His)
目录号: GC27280纯度: 不显示
氨肽酶 N/APN 蛋白是一种二硫键同源三聚体，充当广泛特异性氨肽酶。它在肽消化、肽加工、抗原呈递、血管生成和胆固醇结晶中发挥着至关重要的作用。APN 蛋白还与氨基酸转运蛋白 SLC6A19 相互作用，并在感染过程中充当人类冠状病毒 229E/HCoV-229E 的受体。Aminopeptidase N/APN 蛋白, Human (HEK293, His) 是重组的 氨肽酶 N/APN 蛋白，由 HEK293 表达，带有 C-His 标签。
| 规格 | 价格 | 库存 | 数量 | 操作 |
|---|---|---|---|---|
| 5ug | ¥900.00 | 现货 | 1 | |
| 10ug | ¥1,530.00 | 现货 | 1 | |
| 50ug | ¥4,320.00 | 现货 | 1 |
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文献被引
本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
Nature641, 529–536 (2025)
Nature628, 630–638 (2024)
Nature632, 686–694 (2024)
Nature618, 1017–1023 (2023)
Nature610, 366–372 (2022)
Cell187(9):2288-2304 (2024)
Cell183(7):1867-1883 (2020)
Science388(6745) (2025)
Science387(6739) (2025)
Science387(6734) (2025)
Cell Research35, 97–116 (2025)
Cell Research34, 683–706 (2024)
Cell Research33, 273–287 (2023)
Cell Research33, 546–561 (2023)
Cell Research33, 904–922 (2023)
Cell Research31, 1291–1307 (2021)
产品描述 Description
产品文档 Product Documents
Purity:不显示
Product Data
Purity
Greater than 95% as determined by reducing SDS-PAGE.
Source
HEK293
Physical Appearance
Lyophilized powder.
Shipping Condition
Room temperature in continental US; may vary elsewhere.
Synonyms
rHuAminopeptidase N/APN Protein, His; Aminopeptidase N; ANPEP; AP-M; APN; AP-N; CD13 antigen; CD13; CD13APN; PEPN; PEPNhAPN
Amino Acid Sequence
KAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
Stability
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Biological Activity
Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is >2500 pmoL/min/µg, as measured under the described conditions.
Measured by its ability to cleave the fluorogenic peptide substrate, Ala-7-amido-4-methylcoumarin (Ala-AMC). The specific activity is 1.3946×104 pmol/min/µg, as measured under the described conditions.
Formulation
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4-7.3.