Alphadolone acetate (Alfadolone acetate) is a steroid anaesthetic, with antinociception[1].
Alphadolone acetate (anaesthetized with a 3:1 mixture of Alphaxalone and Alphadolone acetate; i.m.) blocks the oestrogen-stimulated luteinizing hormone (LH) surge and impairs pulsatile secretion in female rats, when combined with alphaxalonet[2].
Alphadolone acetate (14 mL/kg; i.p.; single dosage) decreases serum concentrations of LH in castrated rats[3].
| Animal Model: | Inbred Wistar-derived colony female rats (intramuscularly injected with 20 µg/100g oestradiol benzoate)[2] |
| Dosage: | Anaesthetized with a 3 :1 mixture of Alphaxalone and Alphadolone acetate |
| Administration: | i.m. |
| Result: | Blocked the oestrogen-stimulated LH surge and impairs pulsatile secretion. |
| Animal Model: | Male Sprague-Dawley rats (orchidectomized; aged 90-120 days and weighing 300-350 g)[3] |
| Dosage: | 14 mL/kg |
| Administration: | i.p.; single dosage |
| Result: | Decreased serum concentrations of LH. |
[1]. Nadeson R, et al. Antinociceptive properties of neurosteroids II. Experiments with Saffan and its components alphaxalone and alphadolone to reveal separation of anaesthetic and antinociceptive effects and the involvement of spinal cord GABA(A) receptors. Pain. 2000 Oct;88(1):31-39.
[2]. Dyer RG, Mansfield S. Anaesthesia with alphaxalone plus alphadolone acetate blocks the oestrogen-stimulated LH surge and impairs pulsatile LH secretion in ovariectomized female rats. J Endocrinol. 1984 Jul;102(1):27-31.
[3]. Emanuele MA, et al. Anaesthesia with alphaxalone plus alphadolone acetate decreases serum concentrations of LH in castrated rats. J Endocrinol. 1987 Nov;115(2):221-3.