GlpBio

Allolithocholic Acid-d4

目录号: GC91986纯度: >99.00%同义词: 3α-hydroxy-5α-Cholanoic Acid-d<sub>4</sub>; <em>allo</em>-LCA-d<sub>4</sub>
Allolithocholic Acid-d4旨在用作GC或LC-MS定量异石胆酸的内标。
Allolithocholic Acid-d4
规格价格库存数量操作
1 mg¥1,736.00现货
1
5 mg¥5,320.00现货
1
10 mg¥9,660.00现货
1
500 &#181;g¥966.00现货
1
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文献被引

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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Allolithocholic acid-d4 is intended for use as an internal standard for the quantification of allolithocholic acid by GC- or LC-MS. Allolithocholic acid is a secondary allomonohydroxy bile acid.1 It activates large-conductance calcium-activated potassium channels (BK/KCas; EC50 = 44.21 ?M in Xenopus oocytes expressing the rat channel). Fecal levels of allolithocholic acid are increased in patients with colorectal cancer.2 Allolithocholic acid has also been found in the urine of infants with biliary atresia.3

References:
[1]. Bukiya, A.N., McMillan, J., Parrill, A.L., et al.Structural determinants of monohydroxylated bile acids to activate β1 subunit-containing BK channelsJ. Lipid Res.49(11)2441-2451(2008).
[2]. Tadano, T., Kanoh, M., Kondoh, H., et al.Kinetic analysis of bile acids in the feces of colorectal cancer patients by gas chromatography-mass spectrometry (GC-MS)Rinsho Byori.55(5)417-427(2007).
[3]. Makino, I., Sj?vall, J., Norman, A., et al.Excretion of 3β-hydroxy-5-cholenoic and 3ɑ-hydroxy-5ɑ-cholanoic acids in urine of infants with biliary atresiaFEBS Lett.15(2)161-164(1971).

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

同义词
3α-hydroxy-5α-Cholanoic Acid-d<sub>4</sub>; <em>allo</em>-LCA-d<sub>4</sub>
化学名
(3α,5α)-3-hydroxy-cholan-24-oic-2,2,4,4-d4 acid
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC[C@@]4([H])C([2H])([2H])[C@H](O)C([2H])([2H])C[C@]4(C)[C@@]3([H])CC[C@@]21C
分子式
C24H36D4O3
分子量
380.6 g/mol
溶解性
DMSO: Sparingly soluble: 1-10 mg/ml,Ethanol: Sparingly soluble: 1-10 mg/ml
保存条件
-20&#176;C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol