GlpBio

Alfacalcidol

目录号: GC13799纯度: >99.00%同义词: 阿法骨化醇; 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3
Prodrug of vitamin D3
Alfacalcidol
Cas No.: 41294-56-8
规格价格库存数量操作
5mg¥609.00现货
1
10mg¥998.00现货
1
25mg¥2,027.00现货
1
100mg¥4,893.00现货
1
500mg¥19,572.00现货
1
10mM (in 1mL DMSO)¥1,029.00现货
1
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文献被引

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Alfacalcidol is an analogue of Vitamin D and a potent inhibitor of bone resorption [1].

Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model.

References:
[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.

实验参考方法 Experimental Reference Method

Animal experiment [1]:

Animal models

ovariectomized rat model of osteoporosis

Preparation method

The solubility of this compound in DMSO is >20.1mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Dosage form

0.05, 0.1, and 0.2 μg/kg; orally administered; five times a week for 12 weeks

Application

In ovariectomized rat model of osteoporosis, Alfacalcidol inhibited osteoclastic bone resorption in a dose-dependent way and maintained or even stimulated bone formation. Alfacalcidol increased bone mineral density and improved mechanical strength more effectively than 17b-estradiol.

Other notes

Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.

References:

[1] Shiraishi A1, Takeda S, Masaki T, Higuchi Y, Uchiyama Y, Kubodera N, Sato K, Ikeda K, Nakamura T, Matsumoto T, Ogata E. Alfacalcidol inhibits bone resorption and stimulates formation in an ovariectomized rat model of osteoporosis: distinct actions from estrogen. J Bone Miner Res. 2000 Apr;15(4):770-9.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
41294-56-8
同义词
阿法骨化醇; 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3
化学名
(1R,3S,5E)-5-[(2Z)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
SMILES
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
分子式
C27H44O2
分子量
400.65 g/mol
溶解性
≥ 20.05mg/mL in DMSO
保存条件
Store at -20°C,unstable in solution, ready to use.
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol