IC50: 8.92 nM (AKR1C3)[1]
AKR1C3-IN-9 is a selective inhibitor of cancer cell line[1].
AKR1C3-IN-9 (compound 24) (10-100 μM; 72 h and 96 h) 对 3 种乳腺癌细胞系 (MDA-MB-231、MCF-7) 均有较弱的抗增殖作用，抑制范围为 100 μM[1]。
AKR1C3-IN-9 (10 μM, 25 μM, 50 μM; 72 h) 与 10-50 μM DOX 协同抑制 MCF-7 细胞增殖[1]。
AKR1C3-IN-9 (10 μM; 8 d) 与 50 μM DOX 协同抑制 MCF-7/DOX 细胞系的增殖、克隆生存，从而恢复对 DOX 的敏感性[1]。
[1]. Liu Y, et al. Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur J Med Chem. 2022 Dec 13;247:115013.