AGPS-IN-1 (Compound 2i) is an effective AGPS binder. AGPS-IN-1 reduces ether lipids levels and cell migration rate. AGPS-IN-1 inhibits epithelial-mesencmal transition (EMT) in prostate PC-3 and breast MDA-MB-231 cancer cells.
References:
[1]. Stazi G, et al. Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesencmal transition in cancer cells. Eur J Med Chem. 2019 Feb 1;163:722-735.
















