Adenosine-5'-O-diphosphoribose phosphate (sodium salt)

Adenosine-5’-O-diphosphoribose phosphate (ADP-ribose phosphate) is an inhibitor of HMG-CoA reductase and a derivative of the nucleotide sugar ADP-ribose that is phosphorylated at the 2’ position.¹ It selectively inhibits rat liver microsomal HMG-CoA reductase in its non-allosteric form with apparent K_i values of 53 and 550 µM at high and low thiol concentrations, respectively, which are associated with its non-allosteric and allosteric forms.