ACSS2-IN-2

ACSS2-IN-2, also known as MTB-9655, is a potent inhibitor of acyl-CoA synthetase Short Chain Family Member 2 (ACSS2), with an IC₅₀ value of 0.15nM^[1]. ACSS2-IN-2 can inhibit the activity of ACSS2 and can be used in studies such as tumor metabolism, lipid metabolism and viral infection^[2-3].

References:
[1]Perets R, Geva R, McKean M, et al. Phase 1 first-in-human trial of MTB-9655, the first oral inhibitor of ACSS2, in patients with advanced solid tumors[J]. 2022.
[2]Jiao R, Jiang W, Xu K, et al. Lipid metabolism analysis in esophageal cancer and associated drug discovery[J]. Journal of Pharmaceutical Analysis, 2024, 14(1): 1-15.
[3] Ewida H, Benson H, Tareq S, et al. Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases[J]. ACS Pharmacology & Translational Science, 2024, 8(1): 36-46.

ACSS2-IN-2，也称为MTB-9655，是一种有效的酰基辅酶a合成酶短链家族成员2（ACSS2）抑制剂，IC₅₀值为0.15nM^[1]。ACSS2-IN-2可以抑制ACSS2的活性，可用于肿瘤代谢、脂质代谢、病毒感染等研究^[2-3]。