GlpBio

Ac2-26 (human) (ammonium salt)

目录号: GC49263纯度: >90.00%同义词: Ac-AMVSEFLKQAWFIENEEQEYVQTVK-OH, Ac-ANX-A12-26, N-Acetyl-AMVSEFLKQAWFIENEEQEYVQTVK
An annexin A1-mimetic peptide
Ac2-26 (human) (ammonium salt)
Cas No.: N/A
规格价格库存数量操作
1 mg¥1,001.00现货
1
5 mg¥2,248.00现货
1
10 mg¥3,511.00现货
1
25 mg¥7,515.00现货
1
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文献被引

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    610, 366–372 (2022)
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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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产品描述 Description

Ac2-26 is an annexin A1-mimetic peptide that corresponds to amino acids 2-26 of the N-terminus in annexin A1.1 It binds to HEK293 cells expressing human formyl peptide receptor 1 (FPR1) or FPR2, also known as FPR-like 1 (FPRL1; EC50s = 1.4 and 1.8 µM, respectively, in a radioligand binding assay), as well as inhibits polymorphonuclear leukocyte (PMN) rolling over TNF-α-stimulated human umbilical vein endothelial cells (HUVECs) when used at concentrations of 10 and 30 µM. Ac2-26 (10 and 100 µg/ml) inhibits LPS-induced production of prostaglandin E2 and nitric oxide (NO) in rat microglial cells.2 It decreases pulmonary edema in a rat model of ventilator-induced ischemia-reperfusion injury when administered at doses of 0.5 and 1 mg/kg.3

1.Hayhoe, R.P.G., Kamal, A.M., Solito, E., et al.Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: Indication of distinct receptor involvementBlood107(5)2123-2130(2006) 2.Minghetti, L., Nicolini, A., Polazzi, E., et al.Down-regulation of microglial cyclo-oxygenase-2 and inducible nitric oxide synthase expression by lipocortin 1Br. J. Pharmacol.126(6)1307-1314(1999) 3.Liao, W.-I., Wu, S.-Y., Wu, G.-C., et al.Ac2-26, an annexin A1 peptide, attenuates ischemia-reperfusion-induced acute lung injuryInt. J. Mol. Sci.18(8)1771(2017)

产品文档 Product Documents

Purity:>90.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
N/A
同义词
Ac-AMVSEFLKQAWFIENEEQEYVQTVK-OH, Ac-ANX-A12-26, N-Acetyl-AMVSEFLKQAWFIENEEQEYVQTVK
SMILES
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC([C@H](C)NC([C@H](CCC(N)=O)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@@H](NC([C@H](CCC(O)=O)NC([C@H](CO)NC([C@H](C(C)C)NC([C@H](CCSC)NC([C@H](C)NC(C)=O)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O)=O)=O)=O)=O)=O)=O)=O)=O.[NH4+]
分子式
C141H210N32O44S·NH4
分子量
3107.5 g/mol
溶解性
Water: soluble
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol