A1-28 is a disulfide bond-containing ionizable cationic lipid.[1] It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro.
References:
[1].Liu, J., Chang, J., Jiang, Y., et al.Fast and efficient CRISPR/Cas9 genome editing in vivo enabled by bioreducible lipid and messenger RNA nanoparticlesAdv. Mater.31(33)e1902575(2019).