9CCN is a cholesterol ester and oxidized anionic lipid.[1] It has been found both intracellularly in plaque macrophages and extracellularly in atherosclerotic lesions where it acts as an ‘eat-me’ signal to facilitate phagocytic uptake of apoptotic debris. 9CCN has been used in the formation of lipid nanoparticles (LNPs) for the delivery of antagomiRs, chemically modified oligonucleotides that bind specifically to a particular miRNA, to macrophages in vitro and in vivo.[1],[2]
References:
[1].Maiseyeu, A., Mihai, G., Roy, S., et al.Detection of macrophages via paramagnetic vesicles incorporating oxidatively tailored cholesterol ester: An approach for atherosclerosis imagingNanomedicine (Lond)5(9)1341-1356(2010).
[2].Mallén, A., Narváez-Narváez, D.A., Pujol, M.D., et al.Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophagesEur. J. Pharm. Biopharm.197:114238(2024).