U-46619 is the consensus stable analog of prostaglandin H2/thromboxane A2 (PGH2/TXA2) and has been used as a TXA2 agonist in pharmacologic studies for several decades.1 There have been several hypotheses put forward by scientists studying ω-3 fatty acids stipulating that the agonist activity of TXA3 was substantially different than that of TXA2.2 However, no stable analogs of TXA3 were available to test these theories. δ17-U-46619 is the first direct, stable analog of TXA3 ever synthesized. There are no published reports on its activity to date.
1.Bundy, G.L.The synthesis of prostaglandin endoperoxide analogsTetrahedron Lett.241957-1960(1975)
2.Parent, C.A., Lagarde, M., Venton, D.L., et al.Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranesJ. Biol. Chem.2676541-6547(1992)
