(-)-β-Sesquiphellandrene is a sesquiterpene that has been found in Z. officinale and has antiviral and anticancer activities.1,2 It reduces rhinovirus IB virus replication in a plaque reduction assay (IC50 = 0.44 µM).1 (-)-β-Sesquiphellandrene is cytotoxic to HCT116 cells when used at a concentration of 10 µM.2
1.Denyer, C.V., Jackson, P., and Loakes, D.M.Isolation of antirhinoviral sesquiterpenes from ginger (Zingiber officinale)J. Nat. Prod.57(5)658-662(1994) 2.Agnihotri, V.K., ElSohly, H.N., Khan, S.I., et al.Constituents of Nelumbo nucifera leaves and their antimalarial and antifungal activityPhytochem. Lett.1(2)89-93(2008)