β-Glucogallin is a plant metabolite that has been found in E. officinalis and an aldose reductase 2 inhibitor (IC50 = 17 µM).1 β-Glucogallin (30 µM) inhibits glucose-induced sorbitol accumulation in lenses isolated from a transgenic mouse model overexpressing AKR1B1, the gene encoding human aldose reductase 2. It also reduces methylglyoxal-induced increases in COX-2, IL-6, IL-8, chemokine (C-C motif) ligand 2 (CCL2), and receptor for advanced glycation end products (RAGE) levels in ARPE-19 retinal epithelial cells.2
1.Puppala, M., Ponder, J., Suryanarayana, P., et al.The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalisPLoS One7(4)e31399(2012) 2.Ma, Y., Liu, F., and Xu, Y.Protective effect of β-glucogallin on damaged cataract against methylglyoxal induced oxidative stress in cultured lens epithelial cellsMed. Sci. Monit.259310-9318(2019)