β-D-glucan is a natural non-digestible polysaccharide and high biocompatibility that can be selectively recognized by recognition receptors such as Dectin-1 and Toll-like receptors as well as being easily internalized by murine or human macrophages, which is likely to attribute to a target delivery[1]. β-d-glucan is an enteric delivery vehicle for probiotics[2].
β-D-glucan dissolved in DMSO but not water inhibits MCF-7 cell proliferation in a concentration-dependent manner as measured by BrdU incorporation with an IC50 of ∼164 μg/mL. β-D-glucan dissolved in DMSO inhibits tamoxifen/endocrine-resistant LCC9 and LY2 cell proliferation with IC50 values of 4.6 and 24.2 μg/mL, respectively[3].
[1]. Su Y, et al. pH-sensitive PEG-coated hyper-branched β-d-glucan derivative as carrier for CpG oligodeoxynucleotide delivery. Carbohydr Polym. 2020;246:116621.
[2]. Gani A, et al. β-d-glucan as an enteric delivery vehicle for probiotics. Int J Biol Macromol. 2018;106:864-869.
[3]. Jafaar ZM, et al. β-D-glucan inhibits endocrine-resistant breast cancer cell proliferation and alters gene expression. Int J Oncol. 2014;44(4):1365-1375.