α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine[1].
α-methyl-dl-aspartic acid can significantly reduce the anti-hypertensive activity of Bj-BPP-10c in SHR[2].
α-methyl-dl-aspartic acid (147 mg/kg, i.v.) can diminish the l-citrulline-induced retinal vasodilation in Wistar rats[1].
| Animal Model: | Wistar rats |
| Dosage: | 147 mg/kg |
| Administration: | 147 mg/kg, i.v. |
| Result: | Attenuated the increase of retinal arteriolar diameter induced by L-citrulline. |