α-Isopropylmalate (α-IPM) is the leucine biosynthetic precursor in Yeast[1].
α-Isopropylmalate (500 μM) increases LEU3 protein (Leu3p)-dependent transcription[1].
α-Isopropylmalate (10 mM, 48 h) increases reporter gene expression in preadipocytes (30A5)[2].
[1]. Sze JY, et al. In vitro transcriptional activation by a metabolic intermediate: activation by Leu3 depends on alpha-isopropylmalate. Science. 1992 Nov 13;258(5085):1143-5.
[2]. Guo H, et al. Regulation of transcription in mammalian cells by yeast Leu3p and externally supplied inducer. FEBS Lett. 1996 Jul 22;390(2):191-5.