α-Glucosidase is a carbohydrate hydrolase that catalyzes the release of alpha-glucosidase from the non-reducing end of the substrate. Inhibition of α-Glucosidase is an effective method for non-insulin-dependent diabetes mellitus (NIDDM) [1-2]. Partial or complete deficiency of alpha-glucosidase can cause Pompe disease[3-4].
References:
[1]. Kumar S, Narwal S,et,al. α-glucosidase inhibitors from plants: A natural approach to treat diabetes. Pharmacogn Rev. 2011 Jan;5(9):19-29. doi: 10.4103/0973-7847.79096. PMID: 22096315; PMCID: PMC3210010.
[2]. van de Laar FA, Lucassen PL, ,et,al. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis. Diabetes Care. 2005 Jan;28(1):154-63. doi: 10.2337/diacare.28.1.154. PMID: 15616251.
[3]. Kohler L, Puertollano R, ,et,al. Pompe Disease: From Basic Science to Therapy. Neurotherapeutics. 2018 Oct;15(4):928-942. doi: 10.1007/s13311-018-0655-y. PMID: 30117059; PMCID: PMC6277280.
[4]. Morales A, Anilkumar AC. Glycogen Storage Disease Type II. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470558/
α-葡萄糖苷酶是一种碳水化合物水解酶,催化从底物的非还原端释放α-葡萄糖苷酶。抑制α-葡萄糖苷酶是治疗非胰岛素依赖型糖尿病(NIDDM)的有效方法[1-2]。部分或完全缺乏α -葡萄糖苷酶可引起Pompe病[3-4]。
















