9,11-methane-epoxy Prostaglandin F1α

Prostaglandin (PG) endoperoxides are intermediates in the biosynthesis of PGs, thromboxanes, and prostacyclin. The endoperoxides, PGH₂ and PGG₂, induce rapid and irreversible aggregation of human platelets.¹ PGH₁ and PGG₁ are known to contract smooth muscle preparations, but are lacking in aggregatory effects. 9,11-methane-epoxy Prostaglandin F_1α (9,11-methane-epoxy PGF_1α) is a stable epoxymethano analog of PGH₁ that produces a strong and dose-related aggregation of washed rabbit platelets (EC₅₀ = 0.88 µM) and contraction of rabbit aortic strips (EC₅₀ = 0.11 µM).¹ 9,11-methane-epoxy PGF_1α induces contraction of guinea pig tracheas (EC₅₀ = 3.4 µM) with a maximal contraction of about 60% of that caused by a submaximal dose of histamine.

1.Morita, A., Nishino, H., Hasegawa, K., et al.Biological activities of prostaglandin H1 analogsProstaglandins18(4)529-540(1979)