8S(9R)-EET is an oxylipin and a metabolite of arachidonic acid .[1] It is formed via oxidation of arachidonic acid by the cytochrome P450 (CYP) isoforms CYP1A1, CYP1A2, CYP2B1, and CYP2B2. 8S(9R)-EET induces relaxation of precontracted isolated dog epicardial arterioles (EC50 = 121 pM).[2] Intrarenal infusion of 8S(9R)-EET (0.5, 1, or 2 µg/kg per minute) induces glomerular vasoconstriction and reduces the glomerular filtration rate in rats.[3]
References:
[1].Capdevila, J.H., Karara, A., Waxman, D.J., et al.Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenaseJ. Biol. Chem.265(19)10865-10871(1990).
[2].Zhang, Y., Oltman, C.L., Lu, T., et al.EET homologs potently dilate coronary microvessels and activate BKCa channelsAm. J. Physiol. Heart Circ. Physiol.280(6)H2430-H2440(2001).
[3].Katoh, T., Takahashi, K., Capdevila, J., et al.Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidneyAm. J. Physiol.261(4 Pt 2)F578-F586(1991).