GlpBio

7-Methoxy-4-(trifluoromethyl)coumarin

目录号: GC49248纯度: >95.00%同义词: 7-甲氧基-4-(三氟甲基)香豆素
A fluorogenic substrate for CYPs
7-Methoxy-4-(trifluoromethyl)coumarin
Cas No.: 575-04-2
规格价格库存数量操作
50 mg¥3,219.00现货
1
100 mg¥6,114.00现货
1
250 mg¥13,675.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

7-Methoxy-4-(trifluoromethyl)coumarin is a fluorogenic substrate for cytochrome P450s (CYPs).1 Upon enzymatic cleavage by CYPs, 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) is released and its fluorescence can be used to quantify CYP activity. HFC displays excitation/emission maxima of 410/510 nm, respectively.

1.Donato, M.T., JimÉnez, N., Castell, J.V., et al.Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymesDrug Metab. Dispos.32(7)699-706(2004)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
575-04-2
同义词
7-甲氧基-4-(三氟甲基)香豆素
SMILES
O=C1OC2=C(C(C(F)(F)F)=C1)C=CC(OC)=C2
分子式
C11H7F3O3
分子量
244.2 g/mol
溶解性
DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
保存条件
-20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol