7-Ketodeoxycholic acid is a bile acid derivative that is a metabolite of bile acid in Clostridium absonum. It can also be converted by Lactobacillus and Bifidobacterium under certain conditions[1, 2]. Bile acids are natural steroid amphiphilic compounds formed by cholesterol oxidation in the liver and play a vital role in regulating lipid metabolism[3]. 7-Ketodeoxycholic acid levels are increased in the liver tissue of ethanol-induced alcoholic liver disease (ALD) mice[4]. Patients with non-alcoholic steatohepatitis (NASH) have higher levels of 7-Ketodeoxycholic acid in their plasma[5]. Resistant starch (LRS) can promote the excretion of 7-Ketodeoxycholic acid in hyperlipidemic rats[6].
References:
[1] Sutherland J D, Macdonald I A. The metabolism of primary, 7-oxo, and 7 beta-hydroxy bile acids by Clostridium absonum[J]. Journal of lipid research, 1982, 23(5): 726-732.
[2] Takahashi T, Morotomi M. Absence of cholic acid 7α-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium[J]. Journal of Dairy Science, 1994, 77(11): 3275-3286.
[3] Li T, Chiang J Y L. Regulation of bile acid and cholesterol metabolism by PPARs[J]. PPAR research, 2009, 2009(1): 501739.
[4] Charkoftaki G, Tan W Y, Berrios-Carcamo P, et al. Liver metabolomics identifies bile acid profile changes at early stages of alcoholic liver disease in mice[J]. 2022.
[5] Nimer N. Mass Spectrometry as Discovery Platform for Candidate Metabolite of Non-Alcoholic Steatohepatitis (NASH)[D]. Cleveland State University, 2020.
[6] Lei S, Liu L, Yue P, et al. Lotus seed resistant starch decreases the blood lipid and regulates the serum bile acids profiles in hyperlipidemic rats[J]. Journal of Functional Foods, 2022, 92: 105040.
7-Ketodeoxycholic acid是一种胆汁酸衍生物，是胆汁酸在梭菌（Clostridium absonum）中的代谢产物，也可由乳酸杆菌和双歧杆菌在特定条件下也可转化得到[1, 2]。胆汁酸是通过肝脏中胆固醇氧化形成的天然类固醇两亲化合物，在调节脂质代谢中发挥着至关重要的作用[3]。在乙醇诱导的酒精性肝病（ALD）小鼠的肝脏组织中，7-Ketodeoxycholic acid的水平升高[4]。非酒精性脂肪性肝炎（NASH）患者血浆中具有较高水平的7-Ketodeoxycholic acid[5]。在高脂血症大鼠中抗性淀粉（LRS）能够促进7-Ketodeoxycholic acid的排泄[6]。