7-Hydroxyflavone is a plant flavonoid that has diverse biological activities.1,2,3,4 It inhibits enterovirus 71 (EV71) replication in infected RD cells (EC50 = 19.95 ?M).1 7-Hydroxyflavone (20 ?M) reduces nicotine-induced production of reactive oxygen species (ROS) and cytotoxicity in NRK-52E cells.2 It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 , TNF-α, and IL-6 in RAW 264.7 cells.3 In vivo, 7-hydroxyflavone reduces acetic acid-induced writhing in mice (ED50 = 125 mg/kg).4
1.Wang, J., Su, H., Zhang, T., et al.Inhibition of enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl phosphatePLoS One9(3)e92565(2014) 2.Sengupta, B., Sahihi, M., Dehkhodaei, M., et al.Differential roles of 3-hydroxyflavone and 7-hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cellsPLoS One12(6)e0179777(2014) 3.Jin, Z., Yang, Y.-Z., Chen, J.-X., et al.Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-hydroxyflavone and 7,8-dihydroxyflavoneJ. Pharm. Pharmacol.69(7)865-874(2017) 4.Thirugnanasambantham, P., Viswanathan, S., Mythirayee, C., et al.Analgesic activity of certain flavone derivatives: A structure-activity studyJ. Ethnopharmacol.28(2)207-214(1990)