7α-hydroxy Dehydroepiandrosterone (7α-hydroxy DHEA) is an active metabolite of the endogenous steroid hormone dehydroepiandrosterone .1 7α-hydroxy DHEA is formed from dehydroepiandrosterone via 7-hydroxylation by cytochrome P450s (CYPs).2 It increases antigen-induced production of anti-tetanus toxoid and anti-pertussis antigen IgGs in co-cultures of human tonsil-derived B and T cells when used at a concentration of 1 µM.3 7α-hydroxy DHEA (6.25 mg/kg) increases serum concentrations of anti-lysozyme IgG in mice.1
1.Morfin, R., and Courchay, G.Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in miceJ. Steroid Biochem. Mol. Biol.50(1-2)91-100(1994) 2.Hampl, R., Morfin, R., and Starka, L.7-Hydroxylated derivatives of dehydroepiandrosterone: What are they good for•Endocr. Regul.31(4)211-218(1997) 3.Lafaye, P., Chmielewski, V., Nato, F., et al.The 7α-hydroxysteroids produced in human tonsils enhance the immune response to tetanus toxoid and Bordetella pertussis antigensBiochim. Biophys. Acta1472(1-2)222-231(1999)