6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice.
References:
[1]. Costes S, Butler PC. Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes . Cell Metab. 2014;20(2):201-203.