6-Deoxy-8-O-methylrabelomycin is an anthraquinone that has been found in Pseudonocardia with antiparasitic and antibiotic activities.[1],[2] It is active against the parasite P. berghei (IC50 = 18.5 µM) and the bacterium B. subtilis (MIC = 25 µg/ml) but does not induce cellular toxicity in HepG2 cells (IC50 = >100 µM).[1] 6-Deoxy-8-O-methylrabelomycin is also active against methicillin-resistant S. aureus (MRSA; IC50 = 48 µg/ml) and reduces MRSA production of the virulence factor staphyloxanthin (IC50 = 6 µg/ml).[2]
References:
[1].Carr, G., Derbyshire, E.R., Caldera, E., et al.Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.J. Nat. Prod.75(10)1806-1809(2012).
[2].Sakai, K., Koyama, N., Fukuda, T., et al.Search method for inhibitors of staphyloxanthin production by methicillin-resistant Staphylococcus aureusBiol. Pharm. Bull.35(1)48-53(2012).