6-Azido-hexylamine is a compound widely used in organic synthesis and chemical biology, capable of efficiently forming stable covalent linkages with molecules containing groups such as alkynes, DBCO, or BCN through click chemistry. 6-Azido-hexylamine is a cleavable antibody-drug conjugate (ADC) linker that can be used in the synthesis of antibody-drug conjugates. It enables the specific conjugation of antibodies to cytotoxic molecules via click chemistry, thereby facilitating the development of targeted drug delivery systems[1-2].
References:
[1] Beck A, Goetsch L, Dumontet C, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
[2] Köhn M, Gutierrez-Rodriguez M, Jonkheijm P, et al. A microarray strategy for mapping the substrate specificity of protein tyrosine phosphatase. Angew Chem Int Ed Engl. 2007;46(40):7700-3.
6-Azido-hexylamine是一种在有机合成和化学生物学中应用广泛的化合物，能够通过点击化学反应高效地与含有炔烃、DBCO或BCN等基团的分子形成稳定的共价连接。6-Azido-hexylamine是一种可降解的抗体药物偶联物连接子，可用于合成抗体偶联药物。6-Azido-hexylamine通过点击化学反应实现抗体与细胞毒素分子的特异性连接，从而用于靶向药物递送系统的开发[1-2]。