5-OMe-UTP,100mM Sodium Solution, a modified form of UTP with a methoxy group attached, is a natural analogue of the triphosphate form of uridine [1]. 5-OMe-UTP,100mM Sodium Solution is a potent and selective P2Y6-Receptor agonist[2]. 5-OMe-UTP,100mM Sodium Solution can be used to incorporate into mRNA using T7 RNA polymerase, thereby reducing the activity and immunogenicity of the resulting mRNA[3].
References:
[1] Furtado D, Cortez-Jugo C, Hung Y H, et al. mRNA treatment rescues Niemann–Pick disease type C1 in patient fibroblasts[J]. Molecular Pharmaceutics, 2022, 19(11): 3987-3999.
[2] Ginsburg-Shmuel T, Haas M, Schumann M, et al. 5-OMe-UDP is a potent and selective P2Y6-receptor agonist[J]. Journal of medicinal chemistry, 2010, 53(4): 1673-1685.
[3] Li B, Zeng C, Dong Y. Design and assessment of engineered CRISPR–Cpf1 and its use for genome editing[J]. Nature protocols, 2018, 13(5): 899-914.
5-OMe-UTP,100mM Sodium Solution是UTP的一种修饰形式，连接有一个甲氧基，是尿苷三磷酸形式的天然类似物[1]。5-OMe-UTP,100mM Sodium Solution是一种强效且选择性的P2Y6受体激动剂[2]。5-OMe-UTP,100mM Sodium Solution可通过T7 RNA聚合酶掺入mRNA中，从而降低所得mRNA的活性和免疫原性[3]。