5-OMe-UTP,100mM Sodium Solution是UTP的一种修饰形式，连接有一个甲氧基，是尿苷三磷酸形式的天然类似物。
Sample solution is provided at 25 µL, 10mM.
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5-OMe-UTP,100mM Sodium Solution, a modified form of UTP with a methoxy group attached, is a natural analogue of the triphosphate form of uridine [1]. 5-OMe-UTP,100mM Sodium Solution is a potent and selective P2Y6-Receptor agonist[2]. 5-OMe-UTP,100mM Sodium Solution can be used to incorporate into mRNA using T7 RNA polymerase, thereby reducing the activity and immunogenicity of the resulting mRNA[3].
References:
[1] Furtado D, Cortez-Jugo C, Hung Y H, et al. mRNA treatment rescues Niemann–Pick disease type C1 in patient fibroblasts[J]. Molecular Pharmaceutics, 2022, 19(11): 3987-3999.
[2] Ginsburg-Shmuel T, Haas M, Schumann M, et al. 5-OMe-UDP is a potent and selective P2Y6-receptor agonist[J]. Journal of medicinal chemistry, 2010, 53(4): 1673-1685.
[3] Li B, Zeng C, Dong Y. Design and assessment of engineered CRISPR–Cpf1 and its use for genome editing[J]. Nature protocols, 2018, 13(5): 899-914.
5-OMe-UTP,100mM Sodium Solution是UTP的一种修饰形式，连接有一个甲氧基，是尿苷三磷酸形式的天然类似物[1]。5-OMe-UTP,100mM Sodium Solution是一种强效且选择性的P2Y6受体激动剂[2]。5-OMe-UTP,100mM Sodium Solution可通过T7 RNA聚合酶掺入mRNA中，从而降低所得mRNA的活性和免疫原性[3]。
| Cas No. | SDF | ||
| 分子式 | C10H14N2Na3O16P3 | 分子量 | 580.11 |
| 溶解度 | 储存条件 | Store at -20°C or below, always avoid freeze-thaw cycles. | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7238 mL | 8.6191 mL | 17.2381 mL |
| 5 mM | 344.8 μL | 1.7238 mL | 3.4476 mL |
| 10 mM | 172.4 μL | 861.9 μL | 1.7238 mL |
Quality Control & SDS
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Purity: ≥98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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