5,7-Dichlorothiazolo[5,4-d]pyrimidine is a building block.1,2,3,4 It has been used in the synthesis of a variety of compounds, including spleen tyrosine kinase (Syk), mammalian target of rapamycin (mTOR), and PI3Kδ inhibitors, as well as HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with antiviral activity.
1.Lucas, M.C., Goldstein, D.M., Hermann, J.C., et al.Rational design of highly selective spleen tyrosine kinase inhibitorsJ. Med. Chem.55(23)10414-10423(2012) 2.Bonazzi, S., Goold, C.P., Gray, A., et al.Discovery of a brain-penetrant ATP-competitive inhibitor of the mechanistic target of rapamycin (mTOR) for CNS disordersJ. Med. Chem.63(3)1068-1083(2020) 3.Murray, J.M., Sweeney, Z.K., Chan, B.K., et al.Potent and highly selective benzimidazole inhibitors of PI3-kinase deltaJ. Med. Chem.55(17)7686-7695(2012) 4.Kang, D., Zhao, T., Wang, Z., et al.Discovery of piperidine-substituted thiazolo[5,4-d]pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitorsCommun. Chem.274(2019)