4-Formylcolchicine is a potent anticancer agent. 4-Formylcolchicine shows cytotoxicity activity with IC50 values of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].
4-Formylcolchicine (compound 7) (0-5 µM; 24 h) shows antiproliferative activity with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively[1].
Cell Viability Assay[1]
| Cell Line: | A549, HT-29, HCT116 cells |
| Concentration: | 0-5 µM |
| Incubation Time: | 24 h |
| Result: | Inhibited cell growth with IC50s of 1.007, 0.128, 0.054 µM for A549, HT-29, HCT116 cells, respectively. |
[1]. Yasobu N, et al. Design, Synthesis, and Antitumor Activity of 4-Halocolchicines and Their Pro-drugs Activated by Cathepsin B. ACS Med Chem Lett. 2011 Mar 4;2(5):348-52.