(3R,8S)-Falcarindiol is a polyacetylene that has been found in N. incisum and has diverse biological activities.1,2,3 It is active against M. tuberculosis strain H37Ra (MIC = 6.25 μg/ml).1 (3R,8S)-Falcarindiol is cytotoxic to MCF-7, H1299, and HepG2 cells (IC50s = 29.4, 22.1, and 23.6 μM, respectively).2 It has algicidal activity against H. circularisquama when used at concentrations of 2 and 4 μM.3
1.O'Neill, T., Johnson, J.A., Webster, D., et al.The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarinsJ. Ethnopharmacol.147(1)232-237(2013) 2.Zheng, X., Zheng, X., Zhang, C., et al.Cytotoxic polyacetylenes isolated from the roots and rhizomes of Notopterygium incisumChinese Chem. Lett.30(2)428-430(2019) 3.Tamura, S., Ohno, T., Hattori, Y., et al.Establishment of absolute stereostructure of falcarindiol, algicidal principle against Heterocapsa circularisquama from Notopterygii RhizomaTetrahedron Lett.51(11)1523-1525(2010)