306-N16B is an ionizable cationic lipid.[1] It has been used in the generation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing 306-N16B and encapsulating an mRNA reporter accumulate specifically in the mouse lung primarily in lung endothelial cells. LNPs containing both 306-N16B and 306-O12B and encapsulating mRNA encoding tuberous sclerosis complex 2 (Tsc2), a tumor suppressor, reduce tumor growth in a mouse model of pulmonary lymphangioleiomyomatosis (LAM) induced by intravenous injection of Tsc2-null kidney-derived epithelial tumor cells (TTJ cells).
References:
[1].Qiu, M., Tang, Y., Chen, J., et al.Lung-selective mRNA delivery of synthetic lipid nanoparticles for the treatment of pulmonary lymphangioleiomyomatosisProc. Natl. Acad. Sci. USA119(8)e2116271119(2022).