3-Epideoxycholic acid (EDCA) is a secondary bile acid and an epimer of deoxycholic acid .1 EDCA has been used as a steroidal host compound for the enantioselective purification of (2R,3S)-3-methyl-2-pentanol from its racemates via enclathration.2 Fecal levels of EDCA are decreased in patients with pediatric non-alcoholic fatty liver disease (NAFLD).1
1.Yu, J., Zhang, H., Chen, L., et al.Disease-associated gut microbiota reduces the profile of secondary bile acids in pediatric nonalcoholic fatty liver diseaseFront. Cell. Infect. Microbiol.11698852(2021) 2.Kato, K., Aburaya, K., Miyake, Y., et al.Excellent enantio-selective enclathration of (2R,3S)-3-methyl-2-pentanol in channel-like cavity of 3-epideoxycholic acid, interpreted by the four-location model for chiral recognitionChem. Commun. (Camb.)232872-2873(2003)