3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.[1] [2]I[3] t is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.[4] 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Reference:
[1]. Yamada, H., Miyata, S., Igaki, N., et al. Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. The Journal of Biological Chemisty 269(32), 20275-20280 (1994).
[2]. Kusunoki, H., Miyata, S., Ohara, T., et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care 26(6), 1889-1894 (2003).
[3]. Niwa, T., and Tsukushi, S. 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int.Suppl. 78, S37-S41 (2001).
[4]. Thornalley, P.J., Langborg, A., and Minhas, H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemistry Journal 344(Pt 1), 109-116 (1999).