3-Chlorogentisyl alcohol is a potent E. coli β-glucuronidase inhibitor with an IC50 value of 0.74 μM, an Ki value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies[1].
3-Chlorogentisyl alcohol (compound 1) (20 µM; 24 h) shows antiproliferative activity in Namalwa, U266 cells[1].
Cell Proliferation Assay[1]
| Cell Line: | Namalwa, U266 cells |
| Concentration: | 20 µM |
| Incubation Time: | 24 h |
| Result: | Showed antiproliferative activity with the viability rate of 70.40% and 94.08% in Namalwa, U266 cells, respectively. |
[1]. YichaoGe， et al. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European Journal of Medicinal Chemistry, 2022, 114699.