3′,5′-diOA-dC

3′,5′-diOA-dC is a ligand for the bacterial second messenger, cyclic dinucleotide, and STING agonist cyclic di-GMP composed of oleic acid and deoxycytidine.¹ It assembles with cyclic di-GMP to form supramolecular nanoparticles and has been used to deliver cyclic di-GMP in vitro and in vivo. Intravenous administration of nanoparticles composed of 3′,5′-diOA-dC and cyclic di-GMP decrease tumor weight and volume, increase the number of CD8⁺ T cells, neutrophils, and natural killer (NK) cells in the tumor microenvironment, and increase tumoral levels of TNF-α and IFN-γ in a B16/F10 murine melanoma model.