3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite.1 It binds to thyroid hormone receptor α1 (TRα1), TRβ1, and TRβ2 (EC50s = 0.8, 0.79, and 0.1 µM, respectively, in cell-free assays).2 3,5-T2 (1 pM) stimulates oxygen consumption in perfused livers isolated from rats with hypothyroidism induced by sodium iodide.3 It reduces subcutaneous and epididymal fat mass, as well as decreases serum leptin and cholesterol levels, without affecting body weight in high-fat diet-induced obese mice when administered at a dose of 2.5 µg/g per day.1
1.Jonas, W., Lietzow, J., Wohlgemuth, F., et al.3,5-Diiodo-L-thyronine (3,5-T2) exerts thyromimetic effects on hypothalamus-pituitary-thyroid axis, body composition, and energy metabolism in male diet-induced obese miceEndocrinology156(1)389-399(2015) 2.Ball, S.G., Sokolov, J., and Chin, W.W.3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitroJ. Mol. Endocrinol.19(2)137-147(1997) 3.Horst, C., Rokos, H., and Seitz, H.J.Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-?-thyronineBiochem. J.261(3)945-950(1989)