3'-Azido-ddATP is a monomeric raw material that can be applied for nucleic acid synthesis [1]. 3'-Azido-ddATP can be widely used as a substrate to detect the enzymatic activity of recombinant HIV-1 reverse transcriptase[2].
References:
[1] Herman B D, Schinazi R F, Zhang H, et al. Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′, 3′-dideoxyguanosine-5′-triphosphates as adenosine analogs[J]. Nucleic acids research, 2012, 40(1): 381-390.
[2] Sluis-Cremer N, Koontz D, Bassit L, et al. Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3′-azido-2′, 3′-dideoxypurine nucleosides[J]. Antimicrobial agents and chemotherapy, 2009, 53(9): 3715-3719.
3'-Azido-ddATP是一种单体原料，可用于核酸合成[1]。3′-Azido-ddATP可广泛用作检测重组HIV-1逆转录酶酶活性的底物[2]。