(2R)-Vildagliptin is the isomer of Vildagliptin , and can be used as an experimental control. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC50 of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antiperglycemic activity.
References:
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[2]. Villhauer EB, et al. 1-[[(3-droxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antiperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89.