2H,2H,3H,3H-Perfluorooctanoic acid (5:3 FTCA) is a perfluoroalkyl compound[1].
2H,2H,3H,3H-Perfluorooctanoic acid (5 mg; 48-144h) is a metabolite produced by the fungus Cunninghamella elegans during the biotransformation of 6:2 FTOH. Moreover, 2H,2H,3H,3H-Perfluorooctanoic acid, as the main metabolite, inhibits the activity of CYP enzymes, which are responsible for the biotransformation of 6:2 FTOH by Cunninghamella elegans[1].2H,2H,3H,3H-Perfluorooctanoic acid (10,000μg/L; 100 days) can be degraded by the aerobic bacterium Labrys portucalensis F11 (L. portucalensis F11) into PFHxA, PFPeA, PFBA, PFPrA, 5:3 fluorotelomer unsaturated carboxylic acid (5:3 FTUCA) and 7:2 fluorotelomer unsaturated carboxylic acid (7:2 FTUCA)[2].
References:
[1] Khan MF, Murphy CD. Fluorotelomer alcohols are efficiently biotransformed by Cunninghamella elegans. Environ Sci Pollut Res Int. 2023 Feb;30(9):23613-23623.
[2] Wijayahena MK, Moreira IS, Castro PML, Dowd S, Marciesky MI, Ng C, Aga DS. PFAS biodegradation by Labrys portucalensis F11: Evidence of chain shortening and identification of metabolites of PFOS, 6:2 FTS, and 5:3 FTCA. Sci Total Environ. 2025 Jan 10;959:178348.
2H,2H,3H,3H-perfluorooctanoic acid (5:3 FTCA)是一种全氟烷基化合物[1]。2H,2H,3H,3H-perfluorooctanoic acid (5mg; 48-144h)是真菌Cunninghamella elegans分解6:2 FTOH的代谢产物。并且2H,2H,3H,3H-perfluorooctanoic acid作为主要代谢产物，会抑制CYP酶（Cunninghamella elegans分解6:2 FTOH的酶）的活性[1]。2H,2H,3H,3H-Perfluorooctanoic acid（10,000μg/L; 100 天）可以被需氧细菌 Labrys portucalensis F11(L. portucalensis F11)降解为 PFHxA、PFPeA、PFBA、PFPrA、5:3 氟代烷基不饱和羧酸（5:3 FTUCA）和 7:2 氟代烷基不饱和羧酸(7:2 FTUCA)[2]。