2-nonyl-3-hydroxy-4-Quinolone-d4 is intended for use as an internal standard for the quantification of 2-nonyl-3-hydroxy-4-quinolone by GC- or LC-MS. 2-nonyl-3-hydroxy-4-Quinolone is a bacterial quorum-sensing signal molecule produced by P. aeruginosa.1 It activates a biosensor for the P. aeruginosa gene pqsA, which encodes the first enzyme in the P. aeruginosa biosynthesis of the bacterial quorum-sensing signal molecule 2-heptyl-3-hydroxy-4-quinolone , in a concentration-dependent manner.2
1.Nguyen, A.T., Jones, J.W., Ruge, M.A., et al.Iron depletion enhances production of antimicrobials by Pseudomonas aeruginosaJ. Bacteriol.197(14)2265-2275(2015) 2.Fletcher, M.P., Diggle, S.P., Crusz, S.A., et al.A dual biosensor for 2-alkyl-4-quinolone quorum-sensing signal moleculesEnviron. Microbiol.9(11)2683-2693(2007)